A Literature Review on the Status and Effects of Salvia Divinorum on Cognitive, Affective, and Behavioral Functioning
by
Parker L. Mott
2011
Salvia divinorum is a hallucinogenic herb that was originally used in the Mazatec Indian culture of Oaxaca, Mexico for spiritual and medicinal purposes (Wasson, 1962). Salvia divinorum produces powerful hallucinogenic effects when the leaves are chewed, orally consumed in a liquid state, or dried and smoked. Its active ingredient is Salvinorin-A (Roth et al., 2002; Siebert, 1994), a highly selective kappa-opioid receptor agonist (Roth et al., 2002), that researchers consider to be the most potent naturally occurring hallucinogen (Ortega, Blount & Manchand, 1982; Siebert, 1994; Valdes et al., 1984). In recent years, the use of Salvia divinorum as a recreational drug has become increasingly popular (Vortherms & Roth, 2006), facilitated by the availability of the drug and videos (e.g., YouTub...