The rapid development of Information and Communication Technologies [ICT], which has the ability to completely change the way people communicate and interact with each other and the environment. In this scenario, recently ubiquitous computing is emerging as the new research paradigm that implements a pervasive usage of intelligent computing technologies in the emerging cyber-physical domains. The 2nd International Conference on ubiquitous computing and intelligent information systems [ICUIS 2022] organized by Shree Venkateshwara Hi-Tech Engineering College, Tamil Nadu, India on 10-11, March 2022 aims to develop a new research forum for researchers, academicians and industrialist to share and exchange their potential insights on the design, implementation and analysis of ubiquitous computing models in intelligent information systems.